1 Cosmetology and Dermopharmacy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mures, Romania.
2 Department of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mures, Romania
The use of phytoestrogens in anti-aging cosmetics has generated growing interest, as they have the potential to mimic the effects of estrogens on aging skin without the risks associated with systemic hormone therapy. This narrative review aims to summarize the mechanisms of action of the main classes of phytoestrogens and to evaluate their efficacy for the intended purpose. The existing data, although limited in number, suggest moderate benefits, particularly in cases of photoaging or in postmenopausal women, where estrogen deficiency is a significant factor. However, efficacy is limited by the instability of cutaneous bioavailability, the stability of cosmetic formulations, and the lack of clinical studies conducted over a longer period of time. From a practical standpoint, the inclusion of phytoestrogens in cosmetic products may represent a complementary option for mature skin care; however, at this time, their use should be supplemented with specialized therapeutic interventions. Future research should focus on optimizing delivery systems, standardizing extracts, and conducting well-controlled clinical studies to accurately determine their efficacy and safety for short-, medium-, and long-term use.