There have been significant advances in our understanding of how changes in the fluidity and permeability of the cell membrane can affect drug resistance in cancer. Research has shown that cancer cells often have changes in the fluidity and permeability of their cell membrane that contribute to their resistance to drugs used to treat cancer. These changes may be due to changes in the composition and organization of the lipid bilayer that makes up the membrane, as well as changes in the expression or localization of proteins and other molecules embedded in the membrane. The lipid composition in the tumor cell membrane changes with drug resistance, which can affect the fluidity and permeability of the cell membrane. Reversal of drug resistance can be achieved by altering cell membrane fluidity and permeability. In recent years, there have been numerous studies aimed at understanding the mechanisms underlying these changes and identifying strategies to overcome drug resistance in cancer. This research has led to the development of new drugs and drug delivery systems that are designed to target specific changes in the cell membrane of cancer cells and improve the effectiveness of chemotherapy. Overall, the advances in our understanding of the role of cell membrane fluidity and permeability in drug resistance in cancer have led to the development of new approaches to treat cancer and improve patient outcomes and further research is needed to continue to improve the understanding of these mechanisms and to identify new strategies to overcome drug resistance in cancer. This article highlights the research status and detection methods of cell membrane fluidity and permeability affecting tumor drug resistance.

DOI: https://doi.org/10.2478/abmj-2023-0003