PHYTOCHEMICAL CHARACTERIZATION OF TRANSILVANIAN PRUNELLA VULGARIS

Alexandra GROȘAN 1, Ruxandra ȘTEFĂNESCU 2*, Camil-Eugen VARI 1, George JÎTCĂ 1, Mădălina BĂTRÂNU 3, Lucia Daniela MUNTEAN 4
1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
2 Discipline of Pharmacognosy and Phytotherapy, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
3 Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania
4 Department of Analytical Chemistry and Drug Analysis, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania

Prunella vulgaris L. grows in spontaneous flora of Romania in wet places, fields, meadows, unpopulated areas, both in the sun and in the shade. The plant is rich in phenolic acids (caffeic acid, rosmarinic acid), pentacyclic triterpenic compounds (ursolic, oleanolic, betulinic acid) and flavonoids (rutoside, quercetin). Prunella vulgaris L. has shown numerous pharmacological actions: antioxidant, anti-allergic, antimicrobial, immunostimulatory activities. The aim of the study was to evaluate the phytochemical and pharmacological profile of the leaves and spike inflorescence of Prunella vulgaris L. collected from Romania. The polyphenol content in leaves was found to be 63.78 ± 2.01 mg GAE/g dry weight in the methanolic extract and 45.73 ± 13.87 mg GAE/g in the aqueous extract. In the spike inflorescence, total polyphenol content was 36.44 ± 6.73 mg GAE/g in the methanolic extract and 26.49 ± 2.97 mg GAE/g in the aqueous extract. The results from the antioxidant assays (DPPH and ABTS) were not significantly different between the two herbal drugs. Further studies are needed in order to quantify the active compounds.