Polycystic Ovarian Syndrome (PCOS) is a disease that is characterized by an increased Gonadotropin-Releasing-Hormone (GnRH) pulsatile frequency, causing an altered LH/FSH ratio. More precisely an increased Luteinizing Hormone (LH) secretion compared to a decreased Follicle-Stimulating Hormone (FSH) secretion leads to the development of hyperandrogenism and to a low-level concentration of estrogens and therefore decreased negative estrogenic feedback in the control axis. The purpose of this review is to connect the physiological Hypothalamic-Pituitary-Ovarian (HPO) axis with said pathology and the ensuring discussion about the possible mechanisms of pathogenesis and guidelines for relieving associated symptoms.
Ivan BERGO 1,2, David ECKERT 1,2, Amalia PUȘCAȘ 1, George JÎTCĂ 1*, Amelia TERO-VESCAN 1
1 Department of Biochemistry, George Emil Palade University of Medicine, Pharmacy, Science Technology of Târgu Mureș, Romania
2 Department of Biochemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania, Campus Hamburg - UMCH, Hamburg, Germany
1 Department of Biochemistry, George Emil Palade University of Medicine, Pharmacy, Science Technology of Târgu Mureș, Romania
2 Department of Biochemistry, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania, Campus Hamburg - UMCH, Hamburg, Germany
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